Module 08: Hypothesis Testing in Connectomics

Teaching Deck

Learning Objectives

• Translate biological questions into testable hypotheses
• Select metrics and null models for structural data
• Interpret outcomes with uncertainty discipline
• Separate supported claims from exploratory signals

Session Outcomes

• Learners can complete the module capability target.
• Learners can produce one evidence-backed artifact.
• Learners can state one limitation or uncertainty.

Agenda (60 min)

• 0-10 min: Frame and model
• 10-35 min: Guided practice
• 35-50 min: Debrief and misconception correction
• 50-60 min: Competency check + exit ticket

Capability Target

Design one hypothesis test with metric, null model, and interpretation boundary statement.

Concept Focus

Core Workflow

• Define question and estimand.
• Choose measurable outputs.
• Select null model.
• Test and interpret results.
• Document supported vs unsupported claims.

60-Minute Run-of-Show

• 00:00-08: framing examples.
• 08:00-20: hypothesis drafting.
• 20:00-34: metric/null model selection.
• 34:00-46: interpretation workshop.
• 46:00-60: competency check.

Misconceptions to Watch

• Surface and correct one likely misconception during debrief.

Studio Activity

Create a hypothesis-testing sheet and critique a peer’s interpretation boundaries.

Activity Output Checklist

• Evidence-linked artifact submitted.
• At least one limitation or uncertainty stated.
• Revision point captured from feedback.

Assessment Rubric

• Minimum: coherent hypothesis/metric/null trio.
• Strong: clear uncertainty and non-claim statements.
• Failure: vague hypothesis without measurable endpoint.

Exit Ticket

Write one claim and one explicit non-claim from the same test outcome.

References (Instructor)

• Use module references listed on the module page.

Teaching Materials

• Module page: /modules/module08/
• Slide page: /modules/slides/module08/
• Worksheet: /assets/worksheets/module08/module08-activity.md