Module 20 Activity Worksheet

Module

Module 20: Statistical Models and Inference for Connectomics

Capability Target

Design and execute a connectomics inference plan that includes null-model choice, multiplicity control, uncertainty reporting, and explicit claim boundaries.

Studio Activity Instructions

Evidence and Reasoning Notes

• Claim:
• Evidence:
• Limitation:

Rubric Check

• Minimum pass
  • Null model is justified and constraints are explicit.
  • Multiplicity handling is documented and applied.
  • Claims are partitioned by confidence level.
• Strong performance
  • Demonstrates sensitivity analysis against preprocessing and sampling choices.
  • Reports effect sizes and uncertainty, not significance alone.
  • Provides clear boundaries on generalization.
• Common failure modes
  • Null model choice disconnected from biological question.
  • Selective reporting of significant outcomes.
  • Conflation of exploratory signal with validated inference.

Exit Prompt

Write a 6-8 sentence inference note that includes:

1. hypothesis and estimand,
2. null-model assumptions,
3. multiplicity strategy,
4. one robust conclusion and one unresolved uncertainty.